- idUS
- Listar por autor
Listar por autor "Giraldez Macias, Servando"
Mostrando ítems 1-3 de 3
-
Artículo
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism
Gavilán Dorronzoro, Elena; Giraldez Macias, Servando; Sánchez Aguayo, Inmaculada; Romero Portillo, Francisco; Ruano Caballero, Diego; Daza Navarro, María Paula (Nature, 2015)Targeting the ubiquitin proteasome pathway has emerged as a rational approach in the treatment of human cancers. Autophagy ...
-
Artículo
Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer
Gasca, Jessica; Flores de Mera, María de la Luz; Giraldez Macias, Servando; Tortolero García, María Dolores; Ruiz-Borrego, Manuel; Romero Portillo, Francisco; Japón, Miguel A.; Sáez, Carmen (Impact Journals, 2016)FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins ...
-
Artículo
βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy
Herrero Ruiz, Joaquín; Mora Santos, María del Mar; Giraldez Macias, Servando; Sáez Torres, Carmen; Romero Portillo, Francisco; Japón Rodríguez, Miguel Ángel (Impact Journals, 2014)n mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the ...